@article{soborgpedersenProductionPurification165Er2026,
	title = {Production and Purification of 165Er from Pressed Ho2O3:Al Targets on a 16.5 {MeV} Cyclotron},
	volume = {10},
	rights = {http://creativecommons.org/licenses/by/3.0/},
	issn = {2410-390X},
	url = {https://www.mdpi.com/2410-390X/10/1/14},
	doi = {10.3390/instruments10010014},
	shorttitle = {Production and Purification of 165Er from Pressed Ho2O3},
	abstract = {Erbium-165 (165Er) is an Auger electron emitter with 7.2 electrons per decay and very few other emissions, making it an interesting candidate for Auger electron therapy. We present here a procedure for producing 165Er by the {natHo}(p,n)165Er nuclear reaction on a 16.5 {MeV} medical cyclotron. The target was prepared by pressing a Ho2O3:Al 1:1 (w/w) powder mixture on a Ag disc with a cylindrical depression in the center. With a 0.1 mm Nb foil in front, degrading the energy to 15 {MeV}, and water cooling at the back of the Ag disc, the target could withstand irradiation at currents up to 45 µA without showing any signs of damage. The beam tolerance of the target was also estimated by calculating the temperature and heat dissipation in the target via the numerical solution of the heat transport equations. For a 180 mg target, the production yield was 12.3 ± 1.9 {MBq}/µAh. The separation of two neighboring lanthanides is challenging, which led us to study the distribution coefficients for Er and Ho on commercially available {LN}2 resin for both {HNO}3 and {HCl} eluents. Based on these values, we propose a purification procedure involving two successive {LN}2 columns for separating the 165Er from Ho and Al, followed by a small {TK}221 column to concentrate the final eluate. No radionuclidic impurities were detected, and the chemical impurities found in the final formulation were traces of Ho, Er, Ca, Pb, and Fe. For three different chelators ({DOTA}, {DTPA}, and {CHX}-A″-{DTPA}), the effective molar activity of the final formulation was measured. The stability of the three complexes formed was also assessed upon incubation in mouse serum for 28 h.},
	pages = {14},
	number = {1},
	journaltitle = {Instruments},
	publisher = {Multidisciplinary Digital Publishing Institute},
	author = {Søborg Pedersen, Kristina and Deville, Claire and Borre, Trine and Torabi, Ghazal and Naidoo, Clive and Jensen, Mikael},
	urldate = {2026-03-11},
	date = {2026-03},
	langid = {english},
	keywords = {Auger electron emitter, chemical separation, radiolanthanides, radionuclide production, scientific-publication},
}