@phdthesis{bouteculet_cible_2025,
	title = {De la cible de ¹⁵⁵{Gd} au ¹⁵⁵{Tb}, un radionucléide pour la santé},
	url = {https://theses.hal.science/tel-05299673},
	abstract = {The need for new medical radionuclides continues to grow as treatments become more personalised. The diversity of their decay modes and the variety of their half-lives make them valuable tools for both medical imaging and therapy. An important criterion for their development is the possibility of producing them in sufficient quantities with a high degree of chemical purity (optimisation of chelation chemistry and isotope delivery to target organs) and isotopic purity (minimisation of unnecessary radiation emitted by the radiopharmaceutical). This work has enabled us to propose an alternative method, based on the isotopic separation of a stable precursor of the radionuclide of interest, Terbium-155, with a view to its production by proton irradiation. A number of experiments were carried out, enabling us for the first time to measure the effective production cross-sections of ¹⁵⁵Tb and its contaminants, ¹⁵³Tb, ¹⁵⁴Tb, and ¹⁵⁶Tb, over an energy range compatible with that accessible with most medical cyclotrons. We have thus been able to propose some of the production parameters that will enable us to find the best compromise between a high production rate and a ¹⁵⁵Tb purity compatible with medical needs. The work is carried out within a collaboration that explores the entire production process, from the stable precursor of the radionuclide to the design of a ¹⁵⁵Tb radio-labelled molecule. In addition, comparisons with two theoretical models, TALYS and EMPIRE, have shown the need to complete the nuclear databases, at least for the production of ¹⁵⁴Tb and ¹⁵⁶Tb, in order to make them more predictive.},
	urldate = {2025-12-18},
	school = {Université Paris-Saclay},
	author = {Bouteculet, Morgane},
	month = sep,
	year = {2025},
	note = {Issue: 2025UPASP064},
	keywords = {Activation par protons, Nuclear physics, Physics for health, Physique nucléaire, Physique pour la santé, Production de radioisotopes, Proton activation, Radioisotope production, Theragnostics, Théranostique, user-project-thesis, ¹⁵⁵Tb},
}