%0 Journal Article
%T Resonant laser ionization and mass separation of 225Ac
%V 13
%N 1
%P 1347
%W https://cds.cern.ch/record/2848111
%U https://www.nature.com/articles/s41598-023-28299-4
%X Abstract
            
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac itself. Several techniques to obtain pure
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform off-line resonant ionization mass spectrometry on two samples of
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the
              
                
                  $$^{225}$$
                  
                    
                      
                      225
                    
                  
                
              
              Ac was deposited on a rhenium surface and a ThO
              
                
                  $$_{2}$$
                  
                    
                      
                      2
                    
                  
                
              
              mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%.
%G en
%J Scientific Reports
%A Johnson, Jake D.
%A Heines, Michael
%A Bruchertseifer, Frank
%A Chevallay, Eric
%A Cocolios, Thomas E.
%A Dockx, Kristof
%A Duchemin, Charlotte
%A Heinitz, Stephan
%A Heinke, Reinhard
%A Hurier, Sophie
%A Lambert, Laura
%A Leenders, Benji
%A Skliarova, Hanna
%A Stora, Thierry
%A Wojtaczka, Wiktoria
%D 2023-01-24
%K scientific-publication