TY - JOUR TI - Resonant laser ionization and mass separation of 225Ac AU - Johnson, Jake D. AU - Heines, Michael AU - Bruchertseifer, Frank AU - Chevallay, Eric AU - Cocolios, Thomas E. AU - Dockx, Kristof AU - Duchemin, Charlotte AU - Heinitz, Stephan AU - Heinke, Reinhard AU - Hurier, Sophie AU - Lambert, Laura AU - Leenders, Benji AU - Skliarova, Hanna AU - Stora, Thierry AU - Wojtaczka, Wiktoria T2 - Scientific Reports AB - Abstract $$^{225}$$ 225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $$^{225}$$ 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $$^{225}$$ 225 Ac itself. Several techniques to obtain pure $$^{225}$$ 225 Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform off-line resonant ionization mass spectrometry on two samples of $$^{225}$$ 225 Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the $$^{225}$$ 225 Ac was deposited on a rhenium surface and a ThO $$_{2}$$ 2 mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%. DA - 2023/01/24/ PY - 2023 DO - 10.1038/s41598-023-28299-4 DP - DOI.org (Crossref) VL - 13 IS - 1 SP - 1347 J2 - Sci Rep LA - en SN - 2045-2322 UR - https://www.nature.com/articles/s41598-023-28299-4 AN - https://cds.cern.ch/record/2848111 DB - CDS Y2 - 2023/02/17/16:39:05 KW - scientific-publication ER -