Scientific publications

Webinars and training

Project presentation

Educational resources

PRISMAP outcomes

PRISMAP produces a wide range of results that we make available to you:

As a research project, PRISMAP publishes results in peer-reviewed scientific journals and other non peer-reviewed venues, and also makes detailed reports – called 'deliverables' – available, if they can be made publicly accessible.

We also make available recordings of the webinars and training sessions organised by PRISMAP, along with the material created to describe the project and how it works.

You can also find links to our funded projects page and to our educational resources, which are part of our multi-faceted outcomes.

Publications

Publishable summary

Download the latest project summary detailing the status of PRISMAP as prepared for the EU funding body and the public.

PRISMAP publishable summary – October 2022

PRISMAP sustainability white paper

As PRISMAP aims for long-term sustainability, this white paper identifies different directions to further develop access services and prepare for a mature European medical radionuclide programme PRISMAP+. Here we make a publishable extract of it available.

PRISMAP sustainability white paper – April 2024

Public deliverables

Deliverables are reports to the EU funding body on the results achieved for one or more project tasks.

1.

Cisternino, S., Haddad, F., Kotliarenko, A., Sounalet, T. & Wang, Y.

PRISMAP Deliverable D10.1 - Report on Gd target production.

(2024). https://zenodo.org/doi/10.5281/zenodo.11110642.

2.

Cocolios, T. E.

PRISMAP Deliverable D6.2: Workshops for senior researchers.

(2024). https://zenodo.org/doi/10.5281/zenodo.11842111.

3.

Jensen, M.

Database of packages, documents, approvals.

(Zenodo, 2024). https://zenodo.org/doi/10.5281/zenodo.11109988.

4.

Vreys, R., Duchemin, C., Haddad, F., Viertl, D., D’Alessandria, C., Talip, Z. & Köster, U.

PRISMAP Deliverable D1.2 - Standardised access procedures.

(2024). https://zenodo.org/doi/10.5281/zenodo.11109550.

5.

Cocolios, T. E., Duchemin, C., Mamis, E. & Stora, T.

PRISMAP Deliverable D10.6 - Report on precursor synthesis and related infrared spectroscopy measurements.

(2023). https://zenodo.org/doi/10.5281/zenodo.10091918.

6.

Jensen, M., Duchemin, C. & Talip, Z.

PRISMAP Public Report D9.2 Compliant and efficient transportation.

(Zenodo, 2023). https://zenodo.org/doi/10.5281/zenodo.10069352.

7.

Le Pennec, A.

Deliverable D6.5 MOOC on the basis of In the Heart of Medical Radioactivity.

(2023). doi: 10.5281/ZENODO.10057649

8.

Collins, S.

Nuclear data for day-1 radionuclides.

(2023). doi: 10.5281/ZENODO.8247129

9.

Manzolaro, M., Corradetti, S., Pupillo, G. & Popescu, L.

PRISMAP Deliverable D8.1 - Proceedings book workshop 1.

(2023). https://zenodo.org/record/7913190.

10.

Radzina, M., Mamis, E., Saule, L., Pajuste, E., Kalnina, M., Cocolios, T., Talip, Z. & Stora, T.

Deliverable 5.1 - Questionnaire on industrial and clinical key players and needs.

(2022). doi: 10.5281/ZENODO.7154340

11.

Jensen, M., Naidoo, C., Bertreix, P., Frosio, T., Viertel, D., Köster, U. & Cocolios, T. E.

Prismap D9.1-First public report from the PRISMAP work package 9 (WP9, transport and logistics).

(Zenodo, 2022). https://zenodo.org/record/6606494.

12.

Decristoforo, C., Hayashi, S. F., Bordeau, C., Haddad, F., Viertl, D., Deville, C., Naidoo, C., Pedersen, K. S., Jensen, M., Köster, U., Correia, J. G., Gano, L., Bruchertseifer, F., Baete, K., Mikolajczak, R., Collins, S., Geistlich, S., Van Der Meulen, N., Ponsard, B., Van De Voorde, M. & Campillos, M.

Standards for clinical translation.

(2022). doi: 10.5281/ZENODO.6599181

13.

Cocolios, T. E., Dooms, L., Ferrari, P., Payne, O. & Bernerd, C.

DFT calculations for Ca and Ti containing molecules.

(2022). doi: 10.5281/ZENODO.6607408

All the public deliverables

Scientific publications

Publications in peer-reviewed journals, conference proceedings, book chapters and books.

1.

Mamis, E., Duchemin, C., Berlin, V., Bernerd, C., Bovigny, M., Chevallay, E., Crepieux, B., Gadelshin, V. M., Heinke, R., Hernandez, R. M., Johnson, J. D., Kalniņa, P., Koliatos, A., Lambert, L., Rossel, R. E., Rothe, S., Thiboud, J., Weber, F., Wendt, K., Zabolockis, R. J., Pajuste, E. & Stora, T.

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS.

Pharmaceuticals 17, 390 (2024). doi: 10.3390/ph17030390. Archive: PMC

2.

Korde, A., Patt, M., Selivanova, S. V., Scott, A. M., Hesselmann, R., Kiss, O., Ramamoorthy, N., Todde, S., Rubow, S. M., Gwaza, L., Lyashchenko, S., Andersson, J., Hockley, B., Kaslival, R. & Decristoforo, C.

Position paper to facilitate patient access to radiopharmaceuticals: considerations for a suitable pharmaceutical regulatory framework.

EJNMMI Radiopharmacy and Chemistry 9, 2 (2024). doi: 10.1186/s41181-023-00230-2. Archive: PMC

3.

Santos, J. F., Braz, M. T., Raposinho, P., Cleeren, F., Cassells, I., Leekens, S., Cawthorne, C., Mendes, F., Fernandes, C. & Paulo, A.

Synthesis and Preclinical Evaluation of PSMA-Targeted ¹¹¹ In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier.

Molecular Pharmaceutics 21, 216–233 (2024). doi: 10.1021/acs.molpharmaceut.3c00787. Archive: SCHOLAR

4.

Stora, T., Duchemin, C., Andreazza, W., Aubert, E., Bernerd, C., Cocolios, T., Deschamps, M., Dorsival, A., Duraffourg, M., Fedosseev, V., Somoza, J. F., Gilardoni, S., Grenard, J. L., Heinke, R., Johnson, J., Koliatos, A., Khan, Q., Lambert, L., Mamis, E., Marsh, B., Marzari, S., Mitifiot, C., Pozzi, F., Prvakova, S., Rinchet, J. Y., Rodriguez, J. R., Roesler, S., Rossel, R., Rothe, S., Vollaire, J. & Widorski, M.

CERN-MEDICIS: Operational indicators to support the production of new medical radionuclides by mass-separation.

Journal of Physics: Conference Series 2687, 082039 (2024). doi: 10.1088/1742-6596/2687/8/082039. Archive: https://lirias.kuleuven.be/4140773&lang=en

5.

Khwairakpam, O., Mancheva, R., Au, M., Bernerd, C., Centofante, L., Chrysalidis, K., Crepieux, B., Fedosseev, V., Heinke, R., Marchi, T., Mariotti, E., Marsh, B., Monetti, A., Nicolosi, P., Rothe, S., Scarpa, D., Schuett, M., Stora, T., Andrighetto, A. & Manzolaro, M.

The SPES laser ion source: Time structure, laser enhancement and efficiency measurements with gallium at ISOLDE Offline 2.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 548, 165249 (2024). doi: 10.1016/j.nimb.2024.165249. Archive: CDS

6.

Van Laere, C., Koole, M., Deroose, C. M., De Voorde, M. V., Baete, K., Cocolios, T. E., Duchemin, C., Ooms, M. & Cleeren, F.

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside.

Theranostics 14, 1720–1743 (2024). doi: 10.7150/thno.92775. Archive: PMC

7.

Renaldin, E., Dellepiane, G., Braccini, S., Sommerhalder, A., Zhang, H., Van Der Meulen, N. P., Eichler, R. & Talip, Z.

Study of thulium-167 cyclotron production: a potential medically-relevant radionuclide.

Frontiers in Chemistry 11, 1288588 (2023). doi: 10.3389/fchem.2023.1288588. Archive: BORIS

8.

Radzina, M., Saule, L., Mamis, E., Koester, U., Cocolios, T. E., Pajuste, E., Kalnina, M., Palskis, K., Sawitzki, Z., Talip, Z., Jensen, M., Duchemin, C., Leufgen, K. & Stora, T.

Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?.

EJNMMI Radiopharmacy and Chemistry 8, 27 (2023). doi: 10.1186/s41181-023-00211-5. Archive: PMC

9.

Johnson, J. D., Heines, M., Bruchertseifer, F., Chevallay, E., Cocolios, T. E., Dockx, K., Duchemin, C., Heinitz, S., Heinke, R., Hurier, S., Lambert, L., Leenders, B., Skliarova, H., Stora, T. & Wojtaczka, W.

Resonant laser ionization and mass separation of 225Ac.

Scientific Reports 13, 1347 (2023). doi: 10.1038/s41598-023-28299-4. Archive: CDS

10.

Bernerd, C., Cocolios, T. E., Dooms, L., Ferrari, P. & Payne, O.

DFT calculations of Ti-based molecules clustering with Ar for laser-based enrichment of stable isotopes.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 541, 141–143 (2023). doi: 10.1016/j.nimb.2023.05.040. Archive: CDS

11.

Bernerd, C., Johnson, J., Aubert, E., Au, M., Barozier, V., Bernardes, A.-P., Bertreix, P., Bruchertseifer, F., Catherall, R., Chevallay, E., Chrysalidis, K., Christodoulou, P., Cocolios, T., Crepieux, B., Deschamps, M., Dorsival, A., Duchemin, C., Fedosseev, V., Fernier, P., Heines, M., Heinke, R., Khalid, U., Khan, M., Khan, Q., Lambert, L., Mamis, E., Marsh, B., Marzari, S., Menaa, N., Munos, M., Pozzi, F., Prvakova, S., Ramos, J., Riccardi, F., Rinchet, J.-Y., Rossel, R., Stora, T., Thiboud, J., Vollaire, J., Van Den Bergh, V. & Wojtaczka, W.

Production of innovative radionuclides for medical applications at the CERN-MEDICIS facility.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 542, 137–143 (2023). doi: 10.1016/j.nimb.2023.05.008. Archive: CDS

12.

Boka, G., Dekhtyar, Y., Rocca, M., Sokolov, A. & Sorokins, H.

Weak Electron Emission of Nanodiamond Irradiated with High Energy Electrons.

in 19th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (eds. Dekhtyar, Y. & Saknite, I.) 89, 293–303 (Springer Nature Switzerland, 2023). https://link.springer.com/10.1007/978-3-031-37132-5_37.

13.

Collins, S., Köster, U., Robinson, A., Ivanov, P., Cocolios, T., Russell, B., Fenwick, A., Bernerd, C., Stegemann, S., Johnston, K., Gerami, A., Chrysalidis, K., Mohamud, H., Ramirez, N., Bhaisare, A., Mewburn-Crook, J., Cullen, D., Pietras, B., Pells, S., Dockx, K., Stucki, N. & Regan, P.

Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity.

Applied Radiation and Isotopes 202, 111044 (2023). doi: 10.1016/j.apradiso.2023.111044. Archive: PMC

14.

Heinke, R., Au, M., Bernerd, C., Chrysalidis, K., Cocolios, T. E., Fedosseev, V. N., Hendriks, I., Jaradat, A. A., Kaja, M., Kieck, T., Kron, T., Mancheva, R., Marsh, B. A., Marzari, S., Raeder, S., Rothe, S., Studer, D., Weber, F. & Wendt, K.

First on-line application of the high-resolution spectroscopy laser ion source PI-LIST at ISOLDE.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 541, 8–12 (2023). doi: 10.1016/j.nimb.2023.04.057

15.

Leenders, B., Aerts, A., Cocolios, T. E., Cottenier, S., Houngbo, D. & Popescu, L.

On the feasibility of online terbium extraction at ISOL@MYRRHA.

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 541, 249–252 (2023). doi: 10.1016/j.nimb.2023.05.034

16.

Nigron, E., Guertin, A., Haddad, F., Granger, L., Rayer, M. & Rintaud, A.

Can we reach suitable 161Tb purity for medical applications using the 160Gd(d,n) reaction?.

Applied Radiation and Isotopes 200, 110927 (2023). doi: 10.1016/j.apradiso.2023.110927. Archive: HAL

17.

Pedersen, K. S., Deville, C., Søndergaard, U., Jensen, M. & Jensen, A. I.

Improved procedures for production and purification of 135La from enriched [135Ba]BaCO3 on a 16.5 MeV cyclotron.

Applied Radiation and Isotopes 192, 110612 (2023). doi: 10.1016/j.apradiso.2022.110612. Archive: DTU Orbit

18.

Wang, Y., Sounalet, T., Guertin, A., Nigron, E., Michel, N. & Haddad, F.

Study of terbium production from enriched Gd targets via the reaction 155Gd(d,2n)155Tb.

Applied Radiation and Isotopes 201, 110996 (2023). doi: 10.1016/j.apradiso.2023.110996. Archive: HAL

19.

Saule, L., Radzina, M., Liepa, M., Roznere, L., Lioznovs, A., Ratniece, M., Mamis, E. & Vjaters, E.

Recurrent Prostate Cancer Diagnostics with 18F-PSMA-1007 PET/CT: A Systematic Review of the Current State.

Diagnostics 12, 3176 (2022). doi: 10.3390/diagnostics12123176. Archive: PMC

20.

Ballan, M., Corradetti, S., Manzolaro, M., Meneghetti, G. & Andrighetto, A.

Thermal and Structural Characterization of a Titanium Carbide/Carbon Composite for Nuclear Applications.

Materials 15, 8358 (2022). doi: 10.3390/ma15238358. Archive: PMC

21.

Vermeulen, K., Van de Voorde, M., Segers, C., Coolkens, A., Rodriguez Pérez, S., Daems, N., Duchemin, C., Crabbé, M., Opsomer, T., Saldarriaga Vargas, C., Heinke, R., Lambert, L., Bernerd, C., Burgoyne, A. R., Cocolios, T. E., Stora, T. & Ooms, M.

Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [153Sm]Sm-DOTA-TATE.

Pharmaceutics 14, 2566 (2022). doi: 10.3390/pharmaceutics14122566. Archive: SCK CEN Publications

22.

Colucci, M., Carminati, S., Haddad, F., Nigron, E., Groppi, F. & Manenti, S.

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium.

The European Physical Journal Plus 137, 1180 (2022). doi: 10.1140/epjp/s13360-022-03378-z. Archive: HAL

23.

Mou, L., Martini, P., Pupillo, G., Cieszykowska, I., Cutler, C. S. & Mikołajczak, R.

67Cu Production Capabilities: A Mini Review.

Molecules 27, 1501 (2022). doi: 10.3390/molecules27051501. Archive: PMC

24.

Collins, S., Robinson, A., Ivanov, P., Köster, U., Cocolios, T., Russell, B., Webster, B., Fenwick, A., Duchemin, C., Ramos, J., Chevallay, E., Jakobsson, U., Stegemann, S., Regan, P. & Stora, T.

Half-life determination of 155Tb from mass-separated samples produced at CERN-MEDICIS.

Applied Radiation and Isotopes 190, 110480 (2022). doi: 10.1016/j.apradiso.2022.110480. Archive: cds

25.

Heinke, R., Chevallay, E., Chrysalidis, K., Cocolios, T. E., Duchemin, C., Fedosseev, V. N., Hurier, S., Lambert, L., Leenders, B., Marsh, B. A., van der Meulen, N. P., Sprung, P., Stora, T., Tosato, M., Wilkins, S. G., Zhang, H. & Talip, Z.

Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS.

Frontiers in Medicine 8, 712374 (2021). doi: 10.3389/fmed.2021.712374. Archive: PMC

26.

Decristoforo, C., Neels, O. & Patt, M.

Emerging Radionuclides in a Regulatory Framework for Medicinal Products – How Do They Fit?.

Frontiers in Medicine 8, 678452 (2021). doi: 10.3389/fmed.2021.678452. Archive: PMC

27.

Radchenko, V., Morgenstern, A., Jalilian, A. R., Ramogida, C. F., Cutler, C., Duchemin, C., Hoehr, C., Haddad, F., Bruchertseifer, F., Gausemel, H., Yang, H., Osso, J. A., Washiyama, K., Czerwinski, K., Leufgen, K., Pruszyński, M., Valzdorf, O., Causey, P., Schaffer, P., Perron, R., Maxim, S., Wilbur, D. S., Stora, T. & Li, Y.

Production and Supply of α-Particle–Emitting Radionuclides for Targeted α-Therapy.

Journal of Nuclear Medicine 62, 1495–1503 (2021). doi: 10.2967/jnumed.120.261016. Archive: PMC

All the publications

Funded projects

PRISMAP selects projects for funding and serves as provider of radionuclides and medical application services for these projects.

The selected projects are presented on our access platform with title, leader, keywords, a publishable abstract and, if available, a summary of the results and a list of related publications.

To the funded projects

Publications by funded projects

1.

Sevenois, M. B. et al.

Optimised solid-phase extraction of 211At: Activity balance of 211At, 210At and 210Po after wet chemistry target dissolution.

Radiation Physics and Chemistry 225, 112146 (2024). doi: 10.1016/j.radphyschem.2024.112146. Archive: scopus

2.

Holzleitner, N. et al.

Preclinical Evaluation of Gastrin-Releasing Peptide Receptor Antagonists Labeled with ¹⁶¹ Tb and ¹⁷⁷ Lu: A Comparative Study.

Journal of Nuclear Medicine jnumed.123.266233 (2023). doi: 10.2967/jnumed.123.266233. Archive: pubmed

Webinars and trainings

PRISMAP provides training for the highly multidisciplinary and fragmented research community.

A common understanding and common terms will enable users, service providers and regulators to speak the same language.

Recordings of previous webinars promoted by PRISMAP look at production of radionuclides, regulatory aspects, theranostics.

For a full list of events, webinars and training sessions organised by the project, please visit our events page.

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PRISMAP Webinar 'Isotopes against cancer: Mass purification for search of new treatments' — Thierry Stora

4 Feb 2022

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What is PRISMAP — Thierry Stora

8 Feb 2022

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Novel radionuclides and their production — Mikael Jensen and Ferid Haddad

8 Feb 2022

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EU Pharmaceutical Regulations — Clemens Decristoforo

8 Feb 2022

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Development of Theranostic Radiopharmaceuticals – Eleni Gourni

8 Feb 2022

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Project presentation

With this series of short videos and the flyer, we would like to introduce the project, its goals and its way of working to a wide audience.

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Welcome to PRISMAP

April 2022

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How to apply

May 2022

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PRISMAP project flyer

November 2021

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Educational content

PRISMAP offers education and training resources aimed at high school or early university students, but anyone is welcome to use them.

The available information can be downloaded from the dedicated educational resources section of our website and freely used in educational settings.

To the educational resources