Chemical properties

Ag-111 is usually in monovalent state. Different cyclen based chelators have been reported .

Nuclear properties

Ag-111 decays by β^- emission with a half-life of 7.45 days to stable Cd-111. It emits a medium energy β^- spectrum with 350 keV average energy and 1037 keV maximum energy, similar to e.g. Re-186.

Moreover Ag-111 emits γ-rays at 342.1 keV (6.7%) making it SPECT-imageable with high-energy collimators.

The mean electron energy emitted per decay is 350 keV, the mean photon energy per decay is 26 keV .

Production

Ag-111 is produced indirectly by thermal neutron irradiation of enriched Pd-110 targets in the research reactors of the PRISMAP network: RHF at ILL, BR2 at SCK CEN or MARIA at NCBJ. The short-lived Pd-111 produced upon neutron capture on Pd-110 decays quickly (T_1/2=23.4 min) to Ag-111 via β-minus decay. A radiochemical Ag/Pd separation via ion exchange chromatography leads to n.c.a. Ag-111.

Distribution

Radiochemical separations are performed at Hevesy Laboratory (DTU, Risø, Denmark). Activity will be shipped from there to the users in form of Ag⁺ solution.

Examples of use

• Ag-111 labelled hydroxyapatite particles have been studied preclinically for radiosynovectomy .
• An Ag-111 labelled carbene complex has been studied preclinically for biodistribution studies of silver-based antimicrobials .
• Different methods have been studied to link Ag-111 to antibodies .
• Ag-111 is suited for perturbed angular correlation studies, a highly sensitive technique to characterize the chemical state and chemical environment of silver bound in molecules .