Ag-111 is usually in monovalent state. Different cyclen based chelators have been reported .
Ag-111 decays by β- emission with a half-life of 7.45 days to stable Cd-111. It emits a medium energy β- spectrum with 350 keV average energy and 1037 keV maximum energy, similar to e.g. Re-186.
Moreover Ag-111 emits γ-rays at 342.1 keV (6.7%) making it SPECT-imageable with high-energy collimators.
The mean electron energy emitted per decay is 350 keV, the mean photon energy per decay is 26 keV .
Ag-111 is produced indirectly by thermal neutron irradiation of enriched Pd-110 targets in the research reactors of the PRISMAP network: RHF at ILL, BR2 at SCK CEN or MARIA at NCBJ. The short-lived Pd-111 produced upon neutron capture on Pd-110 decays quickly (T1/2=23.4 min) to Ag-111 via β-minus decay. A radiochemical Ag/Pd separation via ion exchange chromatography leads to n.c.a. Ag-111.
Radiochemical separations are performed at Hevesy Laboratory (DTU, Risø, Denmark). Activity will be shipped from there to the users in form of Ag+ solution.
Examples of use
|Daughter||Decays to stable Cd-111: 100% β-|
|Processing||Ion exchange chromatography|
|Primary Container||2.5 mL borosilicate glass V-vial with silicon rubber screw cap|
|Chemical Form||Ag+ ion in water or weak (<0.1 M) HCl solution (1-2 ml)|
|Radioactive Concentration (gamma spectrometry)||n.a.|
|Appearance||Clear colourless solution|
|Radionuclide identification (gamma spectrometry)||245 keV and 342 keV gamma lines present|
|Radionuclidic Purity (gamma spectrometry)||>99%|
|Chemical purity (ICP-OES)||n.a.|
|Molar activity (ICP-OES)||n.a.|
|Apparent Molar Activity||n.a.|
|Microbiological quality||Bioburden and endotoxin burden can be analysed post release, upon request.|
|Bacterial endotoxin||Bioburden and endotoxin burden can be analysed post release, upon request.|
|pH (pH strips)||Depends on chemical form|
|Activity available||~1 GBq (more to be discussed), few times per year (planning in advance)|
|Activity limit for UN2910 (excepted package) shipment||0.6 GBq in dry state or 60 MBq in liquid form|