Bi 213
45.6 m
β- 0.4...
γ (440...)
α 5.875, 5.558

Chemical properties

Bi-213 is usually employed in trivalent state. It can be labelled with macrocyclic chelators such as DOTA, but other chelators can be considered too . The ionic radius is 117 pm.

Nuclear properties

Bi-213 decays with a half-life of 0.760(1) hours. It decays by 97.8% β- decay to very short-lived Po-213 (T1/2 = 3.7 µs) that decays in turn by 100% ɑ decay to Pb-209 (T1/2 = 3.2 h), further decaying by β- decay to Bi-209. Moreover, Bi-213 decays by 2.2% ɑ decay to Tl-209 (T1/2=2.16 min) that decays via Pb-209 to Bi-209. Including its short-lived Po-213 daughter, the cumulative ɑ emission is 100% per Bi-213 decay with an average ɑ energy of 8.32 MeV.

Bi-213 emits γ-rays at 440.5 keV (25.94(15)%). This enables SPECT-imaging with high energy collimators .

Production

Ac-225 is produced by elution from Th-229 generators. It is loaded onto a generator from which Bi-213 can be eluted .

Distribution

Bi-213 generators will be shipped from the production facility JRC Karlsruhe (JRC, Karlsruhe, International).

Examples of use

  • Bi-213 has been used preclinically and clinically with antibodies and peptides .
  • A clinical trial with Bi-213-DOTA-substance P has shown promising results for glioblastoma therapy .

Purity grades available

preclinical
GLP

No carrier added (n.c.a.)

Yes
ParameterSpecifications
Production routeTh-229→ Ra-225 → Ac-225 generator
DaughterDecay chain of Bi-213 involves radioactive Po-213 or Tl-209 and Pb-209, leading to quasistable Bi-209: cumulative 100% α, 200% β-
Half-life9.92 d for Ac-225 mother, 45.6 min for Bi-213 eluate
ProcessingBi-213 generator
Primary Container
Product GradeGLP, n.c.a.
Physical FormLiquid
Chemical Formdepending on elution protocol
Radioactive Concentration (gamma spectrometry)n.a.
AppearanceClear colourless eluate
Radionuclide identification (gamma spectrometry)440 keV gamma line present
Radionuclidic Purity (gamma spectrometry)
Chemical purity (ICP-OES)n.a.
Molar activity (ICP-OES)n.a.
Apparent Molar Activityn.a.
Microbiological qualitySterile
Bacterial endotoxinn.a.
pH (pH strips)n.a.; depending on labelling conditions
Additional information
Activity availableMax. 1000 MBq reserved for clinical studies every two months, smaller amounts upon request
Activity limit for UN2910 (excepted package) shipment0.6 MBq Ac-225 in liquid form
Other informationRadiochemical purity >95% of radiolabelled compound (e.g. DOTATOC).
Elution protocol is adaptable to the compound to be labelled, depending on the chelator and labeling protocol

Applications

  • SPECT

Point of supply

  • Karlsruhe, Germany

Involved production facilities

JRC, International