Cu 67
61.8 h
β- 0.4, 0.6...
γ 1852, 93, 91...

Chemical properties

In solution Cu-67 is usually in divalent state. It can be radiolabelled with macrocyclic chelators. DOTA is being used, but other, specific copper chelators such as MeCOSar may provide improved stability.

Nuclear properties

Cu-67 decays by β- decay with a half-life of 2.576(5) days to stable Zn-67. It emits a low energy β- spectrum with 145 keV average energy and 561 keV maximum energy based on branching ratios measured in . In addition to β- emission it also emits low energy conversion and Auger electrons , thus emitting in total about 1.2 electrons (with energies above 7 keV) per decay.

Moreover, Cu-67 emits γ-rays at 184.6 keV (44.2%) and 91.3 / 93.3 keV (together 21.1%) which are suitable for SPECT imaging.

The mean electron energy emitted per decay is 148 keV, the mean photon energy per decay is 101 keV .

Production

Cu-67 is produced by deuteron irradiation of enriched Zn-70 targets at the cyclotron ARRONAX .

Distribution

The radiochemical separation is performed at ARRONAX (Nantes, France) and activity will be shipped from there to the users in form of CuCl2 solution.

Examples of use

  • Cu-67 forms a theranostic pair together with Cu-64.
  • Medium energy collimators are recommended for SPECT imaging with Cu-67 .
  • Clinical trials with Cu-67-radioimmunotherapy have been performed in the past.
  • Clinical trials with Cu-67-peptide receptor radionuclide therapy and Cu-67-PSMA radioligand therapy are ongoing.

Purity grades available

research
preclinical

No carrier added (n.c.a.)

Yes
ParameterSpecifications
Production routeZn-70(d,αn)Cu-67
DaughterDecays to stable Zn-67: 100% β-
Half-life61.8 h
Processing2-step column separation
Primary Container2.5 mL borosilicate glass V-vial with silicon rubber screw cap
Product Graden.c.a.
Physical FormLiquid or solid deposit
Chemical FormIn 0.1 M HCl (evaporation to dryness is also possible)
Radioactive Concentration (gamma spectrometry)n.a.
AppearanceClear colourless solution
Radionuclide identification (gamma spectrometry)185 keV gamma line present
Radionuclidic Purity (gamma spectrometry)Not yet defined
Chemical purity (ICP-OES)n.a.
Molar activity (ICP-OES)n.a.
Apparent Molar Activityn.a.
Microbiological qualityn.a.
Bacterial endotoxinn.a.
pH (pH strips)Depends on chemical form
Additional information
Activity available1 GBq on demand (planning in advance)
Activity limit for UN2910 (excepted package) shipment0.7 GBq in dry state or 70 MBq in liquid form
Other information

Applications

  • β-therapy
  • SPECT

Point of supply

  • Nantes, France

Involved production facilities

ARRONAX, France