Chemical properties
In solution Cu-67 is usually in divalent state. It can be radiolabelled with macrocyclic chelators. DOTA is being used, but other, specific copper chelators such as MeCOSar may provide improved stability.
Nuclear properties
Cu-67 decays by β- decay with a half-life of 2.576(5) days to stable Zn-67. It emits a low energy β- spectrum with 145 keV average energy and 561 keV maximum energy based on branching ratios measured in . In addition to β- emission it also emits low energy conversion and Auger electrons , thus emitting in total about 1.2 electrons (with energies above 7 keV) per decay.
Moreover, Cu-67 emits γ-rays at 184.6 keV (44.2%) and 91.3 / 93.3 keV (together 21.1%) which are suitable for SPECT imaging.
The mean electron energy emitted per decay is 148 keV, the mean photon energy per decay is 101 keV .
Production
Cu-67 is produced by deuteron irradiation of enriched Zn-70 targets at the cyclotron ARRONAX .
Distribution
The radiochemical separation is performed at ARRONAX (Nantes, France) and activity will be shipped from there to the users in form of CuCl2 solution.
Examples of use
Parameter | Specifications |
---|---|
Production route | Zn-70(d,αn)Cu-67 |
Daughter | Decays to stable Zn-67: 100% β- |
Half-life | 61.8 h |
Processing | 2-step column separation |
Primary Container | 2.5 mL borosilicate glass V-vial with silicon rubber screw cap |
Product Grade | n.c.a. |
Physical Form | Liquid or solid deposit |
Chemical Form | In 0.1 M HCl (evaporation to dryness is also possible) |
Radioactive Concentration (gamma spectrometry) | n.a. |
Appearance | Clear colourless solution |
Radionuclide identification (gamma spectrometry) | 185 keV gamma line present |
Radionuclidic Purity (gamma spectrometry) | Not yet defined |
Chemical purity (ICP-OES) | n.a. |
Molar activity (ICP-OES) | n.a. |
Apparent Molar Activity | n.a. |
Microbiological quality | n.a. |
Bacterial endotoxin | n.a. |
pH (pH strips) | Depends on chemical form |
Additional information | |
Activity available | 1 GBq on demand (planning in advance) |
Activity limit for UN2910 (excepted package) shipment | 0.7 GBq in dry state or 70 MBq in liquid form |
Other information |