Ra 223
11.4 d
α 5,716, 5,607...
γ 269, 154, 324...

Chemical properties

Ra-223 is usually in divalent state.

Nuclear properties

Ra-223 decays with by ɑ decay with a half-life of 11.43(5) days. Its' decay chain involving Rn-219 (T1/2 = 4 s), Po-215 (T1/2 = 1.8 ms), Pb-211 (T1/2 = 36 min), Bi-211 (T1/2 = 2.2 min) and Tl-207 (T1/2 = 4.8 min) leads to stable Pb-207. Including its short-lived decay chain, the cumulative ɑ emission is 400% per Ra-223 decay.

Ra-223 emits X-rays from 81 to 98 keV (49.6%) and γ-rays, notably 269 keV (13.3%), its daughter Rn-219 emits γ-rays at 271 keV (10.8%) and Bi-211 emits γ-rays at 351 keV (13%). These are the principal photon emissions of the decay chain that enable SPECT-imaging , .

Production

Ra-223 is produced at JRC Karlsruhe by separation from an Ac-227/Th-227 generator.

Distribution

Radiochemical separations are performed at the production facility JRC Karlsruhe (JRC, Karlsruhe, International). Activity will be shipped from there to the users in dry form.

Examples of use

  • The main application of Ra-223 is as free Ra2+ ions, that act, analogously to Ca2+, as bone seekers. Administered as Ra-223 chloride under the product name Xofigo it is used for targeted therapy of bone metastases of metastatic prostate cancer .
  • Stable chelation of Ra2+ with the chelator macropa has been reported .
  • Encapsulation of Ra-223 in liposomes or radiolabeled nanoparticles , is being investigated.
  • Radiolabeled nanomicelles are being investigated for enhanced effect on bone metastases or combined alpha and beta therapy respectively .

Purity grades available

research
preclinical

No carrier added (n.c.a.)

Yes
ParameterSpecifications
Production routeAc-227→Th-227→Ra-223 generator
DaughterDecay chain involving radioactive Rn-219, Po-215, Pb-211, Bi-211, Tl-207 leading to stable Pb-207: cumulative 400% α, 200% β-
Half-life11.4 d
Processing
Primary Container2.5 mL borosilicate glass V-vial with silicon rubber screw cap
Product GradePreclinical, n.c.a.
Physical FormSolid
Chemical FormDried nitric or chloridic form
Radioactive Concentration (gamma spectrometry)n.a.
AppearanceDried solid
Radionuclide identification (gamma spectrometry)154 keV, 269 keV and 324 keV gamma lines present
Radionuclidic Purity (gamma spectrometry)n.a.
Chemical purity (ICP-OES)n.a.
Molar activity (ICP-OES)n.a.
Apparent Molar Activityn.a.
Microbiological qualityn.a.
Bacterial endotoxinn.a.
pH (pH strips)n.a.
Additional information
Activity availableFew MBq upon request
Activity limit for UN2910 (excepted package) shipment7 MBq in dry state
Other information

Applications

  • α-therapy

Point of supply

  • Karlsruhe, Germany

Involved production facilities

JRC, International