Mn 52
5.6 d
ε
β+ 0.6...
γ 1434, 936, 744...

Chemical properties

In solution Mn-52 is usually in divalent state. It can be radiolabelled with macrocyclic chelators. DOTA is being used, and others are proposed .

Nuclear properties

Mn-52 decays with a half-life of 5.59 days by β+ decay (29.4(4)%) or electron capture (70.6%) to stable Cr-52. The emitted positrons have 242 keV average energy and 575 keV maximum energy.

Mn-52 emits a nearly prompt (41 ps level half-life) cascade of three hard γ-rays: 1434.1 keV (100%), 935.5 keV (94.5%) and 744.2 keV (90%) .

Hence, Mn-52 is a long-lived PET isotope with short positron range (similar to F-18) and good intrinsic resolution, but potential cross-talk from prompt γ-rays emission and significant γ dose rate.

The total electron energy emitted per decay is 74 keV, the total photon energy per decay is 3446 keV .

Production

Mn-52 is produced by proton irradiation of natural Cr targets at Hevesy Laboratory at DTU.

Distribution

The radiochemical separation is performed at Hevesy Laboratory (DTU, Risø, Denmark). Activity will be shipped from there to the users in solution or in form of a dried deposit respectively.

Examples of use

  • Mn-52 has been used for in vivo immune-PET imaging , , .
  • Mn-52 is suited for combined PET/MR imaging or as PET analog of Mn-based MRI contrast agents to study their in vivo distribution and pharmacokinetics , , , .
  • Mn-52 can serve as surrogate for Ca2+ uptake studies, e.g. related to diabetes .
  • Mn-52 has been used for in vivo stem cell tracking .
  • Mn-52 labelled liposomes have been evaluated in vivo .
  • Mn-52 has been used to visualize neuronal tracts , .
  • The radiation effective dose of Mn-52 administered as chloride to humans has been determined and radiation toxicity has been evaluated in rats .

Purity grades available

research
preclinical

No carrier added (n.c.a.)

Yes
ParameterSpecifications
Production routeCr-52(p,n)Mn-52
DaughterDecays to stable Cr-52: 29.4% β+, 70.6% EC
Half-life5.59 d
ProcessingMulti-step ion exchange chromatography
Primary Container2.5 mL borosilicate glass V-vial with silicon rubber screw cap
Product Graden.c.a.
Physical FormLiquid or dried deposit
Chemical FormMn2+ ion in 0.1 M HCl solution (1-2 ml)
Radioactive Concentration (gamma spectrometry)n.a.
AppearanceClear colourless solution or invisible dried deposit
Radionuclide identification (gamma spectrometry)744 keV, 936 keV and 1434 keV gamma lines and 511 keV annihilation gammas present
Radionuclidic Purity (gamma spectrometry)>99%
Chemical purity (ICP-OES)n.a.
Molar activity (ICP-OES)> 200 GBq/µmol Mn at End Of Chemistry (>30% of theoretical maximum)
Apparent Molar Activityn.a.
Microbiological qualityBioburden and endotoxin burden can be analysed post release, upon request
Bacterial endotoxinBioburden and endotoxin burden can be analysed post release, upon request
pH (pH strips)Depends on chemical form
Additional information
Activity availableUp to 0.4 GBq, upon request
Activity limit for UN2910 (excepted package) shipment0.3 GBq in dry state or 30 MBq in liquid form
Other information

Applications

  • PET

Point of supply

  • Risø, Denmark

Involved production facilities

DTU, Denmark