In solution Mn-52 is usually in divalent state. It can be radiolabelled with macrocyclic chelators. DOTA is being used, and others are proposed .
Mn-52 decays with a half-life of 5.59 days by β+ decay (29.4(4)%) or electron capture (70.6%) to stable Cr-52. The emitted positrons have 242 keV average energy and 575 keV maximum energy.
Mn-52 emits a nearly prompt (41 ps level half-life) cascade of three hard γ-rays: 1434.1 keV (100%), 935.5 keV (94.5%) and 744.2 keV (90%) .
Hence, Mn-52 is a long-lived PET isotope with short positron range (similar to F-18) and good intrinsic resolution, but potential cross-talk from prompt γ-rays emission and significant γ dose rate.
The total electron energy emitted per decay is 74 keV, the total photon energy per decay is 3446 keV .
Mn-52 is produced by proton irradiation of natural Cr targets at Hevesy Laboratory at DTU.
The radiochemical separation is performed at Hevesy Laboratory (DTU, Risø, Denmark). Activity will be shipped from there to the users in solution or in form of a dried deposit respectively.
|Daughter||Decays to stable Cr-52: 29.4% β+, 70.6% EC|
|Processing||Multi-step ion exchange chromatography|
|Primary Container||2.5 mL borosilicate glass V-vial with silicon rubber screw cap|
|Physical Form||Liquid or dried deposit|
|Chemical Form||Mn2+ ion in 0.1 M HCl solution (1-2 ml)|
|Radioactive Concentration (gamma spectrometry)||n.a.|
|Appearance||Clear colourless solution or invisible dried deposit|
|Radionuclide identification (gamma spectrometry)||744 keV, 936 keV and 1434 keV gamma lines and 511 keV annihilation gammas present|
|Radionuclidic Purity (gamma spectrometry)||>99%|
|Chemical purity (ICP-OES)||n.a.|
|Molar activity (ICP-OES)||> 200 GBq/µmol Mn at End Of Chemistry (>30% of theoretical maximum)|
|Apparent Molar Activity||n.a.|
|Microbiological quality||Bioburden and endotoxin burden can be analysed post release, upon request|
|Bacterial endotoxin||Bioburden and endotoxin burden can be analysed post release, upon request|
|pH (pH strips)||Depends on chemical form|
|Activity available||Up to 0.4 GBq, upon request|
|Activity limit for UN2910 (excepted package) shipment||0.3 GBq in dry state or 30 MBq in liquid form|