La-135 is a radiolanthanide, usually in trivalent state. La3+ can be chelated e.g. with DTPA or DOTA. The ionic radius of La3+ is 103 pm, i.e. the largest among the lanthanides and close to that of Ac3+ which has 112 pm. It might thus serve as close surrogate for Ac-225 labelling studies.
La-135 emits X-rays, notably Kα at ≈32 keV (61.3(10)%) and Kβ at ≈37 keV (13.4(19) %). These energies make La-135 suitable for SPECT imaging with low-energy detectors. La-135 emits only few γ-rays, namely at 480.5 keV (1.52%).
The mean photon energy per decay is 35 keV and the mean electron energy emitted per decay is 5 keV . Most electrons are short-range Auger electrons with <0.6 µm and <13 µm respectively . La-135 has therefore been proposed as therapeutic Auger electron emitter.
La-135 is produced by proton irradiation of enriched Ba-135 carbonate targets at Hevesy Laboratory at DTU. After decay of short-lived co-produced activities a La/Ba separation is performed by multi-step ion exchange.
Activity will be shipped from Hevesy Laboratory (DTU, Risø, Denmark) to the users in form of La3+ solution.
|Daughter||Decays to stable Ba-135: 99.993% EC, 0.007% β+|
|Processing||Multi-step ion exchange chromatography|
|Primary Container||2.5 mL borosilicate glass V-vial with silicon rubber screw cap|
|Chemical Form||La3+ ion in 0.1 M HCl solution (1-2 ml)|
|Radioactive Concentration (gamma spectrometry)||n.a.|
|Appearance||Clear colourless solution|
|Radionuclide identification (gamma spectrometry)||481 keV and 875 keV gamma lines present|
|Radionuclidic Purity (gamma spectrometry)||>99%|
|Chemical purity (ICP-OES)||Metal impurities determined by ICP-OES for each batch. Typical 25 nmol Al, 5 nmol Ba, 1-2 nmol Fe, Zn per batch (subject to revision)|
|Molar activity (ICP-OES)||Typical 1000 GBq/µmol La at End Of Chemistry (>15% of theoretical maximum)|
|Apparent Molar Activity||n.a.|
|Microbiological quality||Bioburden and endotoxin burden can be analysed post release, upon request.|
|Bacterial endotoxin||Bioburden and endotoxin burden can be analysed post release, upon request.|
|pH (pH strips)||1|
|Activity available||< 1 GBq upon request|
|Activity limit for UN2910 (excepted package) shipment||20 MBq in dry state or 2 MBq in liquid form|