Yb 175
4.16 d
β- 0.5...
γ 396, 283, 114...

Chemical properties

Yb-175 is a radiolanthanide, most often in trivalent state and chemically very similar to lutetium. The ionic radius of Yb3+ is 87 pm, i.e. differing by less than 1% from that of Lu3+, which explains that macrocyclic chelators suitable for Lu-177 can be directly employed for Yb-175 too, in particular DOTA. The ionic radius is 86.8 pm.

Nuclear properties

Yb-175 decays by β- emission with a half-life of 4.1615(30) days to stable Lu-175. In addition to low-energy β- emission (mean energy 113 keV, maximum energy 470 keV) it shows emission of low energy conversion and Auger electrons , thus emitting in total about 1.17 electrons (with energies above 6 keV) per decay.

Moreover Yb-175 emits γ-rays- and X-rays, notably 396.3 keV (13.2(3)%) and 282.5 keV (6.13(8)%). These make Yb-175 suitable for SPECT imaging with high energy collimators.

The mean electron energy emitted per decay is 120 keV, the mean photon energy per decay is 80 keV.

Production

Yb-175 is produced by thermal neutron irradiation of enriched Yb-174 oxide targets in the high flux reactors of the production facilities: RHF at ILL or BR2 at SCK CEN.

Distribution

Off-line mass separation is performed at the production facility MEDICIS (CERN, Geneva, Switzerland). Activity will be shipped from there to the users in form of YbCl3 solution or in solid form, implanted into an Al, Zn or NaCl layer.

Purity grades available

research
preclinical

No carrier added (n.c.a.)

Available in n.c.a. form (but not in theoretical specific activity)
ParameterSpecifications
Production routeYb-174(n,γ)Yb-175
DaughterDecays to stable Lu-175: 100% β-
Half-life4.16 d
ProcessingOff-line mass separation + 2-step column separation
Primary Container2.5 mL borosilicate glass V-vial with silicon rubber screw cap
Product Graden.c.a. (but not in theoretical molar activity)
Physical FormLiquid
Chemical FormIn 0.05 M HCl
Radioactive Concentration (gamma spectrometry)n.a.
AppearanceClear solution
Radionuclide identification (gamma spectrometry)283 keV and 396 keV gamma lines present
Radionuclidic Purity (gamma spectrometry)>99.9%
Chemical purity (ICP-OES)n.a.
Molar activity (ICP-OES)n.a.
Apparent Molar Activityn.a.
Microbiological qualityn.a.
Bacterial endotoxinn.a.
pH (pH strips)n.a.
Additional information
Activity availableUp to 200 MBq few times per year (planning in advance), depends on reactor and MEDICIS schedule
Activity limit for UN2910 (excepted package) shipment0.9 GBq in dry state or 90 MBq in liquid form
Other informationResearch grade implanted in Al, Zn or NaCl layer on gold foil also possible

Applications

  • β-therapy

Point of supply

  • Geneva, Switzerland

Involved production facilities

ILL, France
SCK CEN, Belgium
CERN, International