Chemical properties
Bi-213 is usually employed in trivalent state. It can be labelled with macrocyclic chelators such as DOTA, but other chelators can be considered too . The ionic radius is 117 pm.
Nuclear properties
Bi-213 decays with a half-life of 0.760(1) hours. It decays by 97.8% β- decay to very short-lived Po-213 (T1/2 = 3.7 µs) that decays in turn by 100% ɑ decay to Pb-209 (T1/2 = 3.2 h), further decaying by β- decay to Bi-209. Moreover, Bi-213 decays by 2.2% ɑ decay to Tl-209 (T1/2=2.16 min) that decays via Pb-209 to Bi-209. Including its short-lived Po-213 daughter, the cumulative ɑ emission is 100% per Bi-213 decay with an average ɑ energy of 8.32 MeV.
Bi-213 emits γ-rays at 440.5 keV (25.94(15)%). This enables SPECT-imaging with high energy collimators .
Production
Ac-225 is produced by elution from Th-229 generators. It is loaded onto a generator from which Bi-213 can be eluted .
Distribution
Bi-213 generators will be shipped from the production facility JRC Karlsruhe (JRC, Karlsruhe, International).
Examples of use
| Parameter | Specifications |
|---|---|
| Production route | Th-229→ Ra-225 → Ac-225 generator |
| Daughter | Decay chain of Bi-213 involves radioactive Po-213 or Tl-209 and Pb-209, leading to quasistable Bi-209: cumulative 100% α, 200% β- |
| Half-life | 9.92 d for Ac-225 mother, 45.6 min for Bi-213 eluate |
| Processing | Bi-213 generator |
| Primary Container | |
| Product Grade | GLP, n.c.a. |
| Physical Form | Liquid |
| Chemical Form | depending on elution protocol |
| Radioactive Concentration (gamma spectrometry) | n.a. |
| Appearance | Clear colourless eluate |
| Radionuclide identification (gamma spectrometry) | 440 keV gamma line present |
| Radionuclidic Purity (gamma spectrometry) | |
| Chemical purity (ICP-OES) | n.a. |
| Molar activity (ICP-OES) | n.a. |
| Apparent Molar Activity | n.a. |
| Microbiological quality | Sterile |
| Bacterial endotoxin | n.a. |
| pH (pH strips) | n.a.; depending on labelling conditions |
| Additional information | |
| Activity available | Max. 1000 MBq reserved for clinical studies every two months, smaller amounts upon request |
| Activity limit for UN2910 (excepted package) shipment | 0.6 MBq Ac-225 in liquid form |
| Other information | Radiochemical purity >95% of radiolabelled compound (e.g. DOTATOC). Elution protocol is adaptable to the compound to be labelled, depending on the chelator and labeling protocol |